Abstract #3336

Cognitive Brain Networks in Adult Fetal Alcohol Syndrome: Analyses of Functional Connectivity with a Higher Criticism Approach

Benedikt Sundermann^1,2,3, Reinhold Feldmann⁴, Christian Mathys^1,3, Johanna Rau⁵, Stefan Garde^2,6, Anna Braje², Josef Weglage⁴, and Bettina Pfleiderer²

¹Institute of Radiology and Neuroradiology, Evangelisches Krankenhaus Oldenburg, Medical Campus University of Oldenburg, Oldenburg, Germany, ²Clinic of Radiology, Medical Faculty, University of Münster, Münster, Germany, ³Research Center Neurosensory Science, University of Oldenburg, Oldenburg, Germany, ⁴Department of General Pediatrics, University Hospital Münster, Münster, Germany, ⁵Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany, ⁶Bergman Clinics Augenklinik Universitätsallee Bremen, Bremen, Germany

Synopsis

Keywords: Brain Connectivity, fMRI (resting state)Functional connectivity (FC) between and within a majority of cognition-related brain networks is altered in young adults with Fetal Alcohol Syndrome. Findings in a network-level analysis of resting-state fMRI data with a Higher Criticism approach were most obvious within a dorsal attention subnetwork and to a lesser extent in a salience / ventral attention subnetwork. When analyzing these effects further by looking at single connections, no individual FC alteration was statistically significant when adjusting for multiple comparisons. The finding of a wide distribution of FC alterations across networks might help resolve partially contradictory results in previous studies.

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