Abstract #3337

Intrinsic brain abnormalities in chronic rhinosinusitis and the effect of mood and cognitive function: a resting-state functional MRI study

SIMIN LIN¹, MIAOMIAO NIE², BINGSHAN WANG³, and YI HAN⁴

¹Radiology, Xiamen Cardiovascular Hospital of Xiamen University, Xiamen, China, ²Radiology, Zhongshan Hospital of Xiamen University, Xiamen, China, ³Zhongshan Hospital of Xiamen University, Xiamen, China, ⁴Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University, Xiamen, China

Synopsis

Keywords: Brain Connectivity, fMRI (resting state), Amplitude of low-frequency fluctuationChronic rhinitis (CRS) is one of the most prevalent chronic diseases that increases the risk of anxiety, depression and cognitive disorders. Here we collected rs-fMRI data to assess global brain activity and functional connectivity (FC) in CRS patients. Compared with controls, CRS patients demonstrated increased ALFF in the left orbital superior frontal cortex and decreased FC in the right precuneus cortex, with the former positively correlated with the severity of inflammation and the scores of anxiety and depression. These rs-fMRI studies provided several important hints into the potential neural mechanism related to mood and cognitive dysfunctions in CRS patients.

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