Keywords: Brain Connectivity, fMRI (resting state), Subthreshold depressionThe underlying mechanisms of bright light therapy in prevention of individuals with subthreshold symptoms are unclear. This study aimed to assess the midbrain monoamine-producing nuclei treatment–related functional connectivity changes and their correlation to depressive symptom improvements in subthreshold depression. A total of 74 young adults with subthreshold depression were randomly assigned to receive 8-week BLT (N = 38) or placebo (N = 36). The dorsal raphe nucleus, ventral tegmental area, and habenula seed-based whole-brain FC were analyzed. In addition, a multivariate regression model examined whether baseline brain FC was associated with changes in scores on HDRS during BLT treatment.
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