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Abstract #3339

Altered intrinsic brain functional network dynamics in drug-naïve, first-episode adolescents with major depressive disorder

Baolin Wu1, Zhiyun Jia1,2, and Qiyong Gong1
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, China

Synopsis

Keywords: Psychiatric Disorders, fMRI (resting state)This study aimed to explore the dynamic FC in adolescent MDD patients, with a focus on the temporal properties of functional connectivity states as well as the variability of network topological organization. We found that adolescent MDD patients spent more time in the weakly-connected and relatively highly-modularized State 1, spent less time in the strongly-connected and low-modularized State 2, and had higher variability in the network efficiency than healthy controls. These findings suggest impaired local segregation and global integration of functional networks, as well as segregation-integration imbalance in adolescent MDD patients.

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