Abstract #3342

Altered static and dynamic spontaneous neural activity in adolescent with first episode major depressive disorder and previous suicide attempts

Xiaofang Cheng^1,2, Jianshan Chen¹, Xiaofei Zhang¹, Ting Wang³, Jiaqi Sun¹, Yanling Zhou¹, Ruilan Yang¹, Yeyu Xiao³, Amei Chen³, Ziyi Song¹, Pinrui Chen¹, Chanjuan Yang¹, Qiuxia Wu¹, Taifeng Lin¹, Yingmei Chen¹, Yongzhou Xu⁴, Liping Cao¹, and Xinhua Wei²

¹The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China, ²South China University of Technology, Guangzhou, China, ³Guangzhou Integrated Traditional Chinese and Western Medicine, Guangzhou, China, ⁴Philips Healthcare, Guangzhou, China

Synopsis

Keywords: Brain Connectivity, Adolescents, Major depressive disorder; suicide; frontal cortexThis study combined dynamic and static amplitude of low-frequency fluctuations (ALFF) approaches to investigate the differences in local spontaneous brain activities between depressed adolescents with and without suicide attempts (SA). Our findings suggest that alterations in brain activities in regions involved in emotional processing, decision-making, and response inhibition are associated with an increased risk of suicidal behaviors in depressed adolescents.

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