Abstract #3345

Alterations of static and dynamic functional connectivity in adolescents with first-episode major depression and suicidal tendencies

Xiaofang Cheng^1,2, Jianshan Chen¹, Xiaofei Zhang¹, Ting Wang³, Jiaqi Sun¹, Yanling Zhou¹, Ruilan Yang¹, Yeyu Xiao³, Amei Chen³, Ziyi Song¹, Pinrui Chen¹, Chanjuan Yang¹, Qiuxia Wu¹, Taifeng Lin¹, Yingmei Chen¹, Yongzhou Xu⁴, Liping Cao¹, and Xinhua Wei²

¹The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China, ²South China University of Technology, Guangzhou, China, ³Guangzhou Integrated Traditional Chinese and Western Medicine, Guangzhou, China, ⁴Philips Healthcare, Guangzhou, China

Synopsis

Keywords: Brain Connectivity, Adolescents, major depressive disorder; suicide; FCSThis study used graph theory-based dynamic and static functional connectivity strength (FCS) approaches to investigate the differences in global brain connectivity patterns in depressed adolescents with and without suicide attempts. Our findings suggest that abnormal connectivity patterns in multiple brain regions involving cognition and emotion control, and self-referential processing are associated with the increasing risk of vulnerability to a suicide attempt in depressed adolescents.

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