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Abstract #3351

Anesthetic modulation of water diffusion: Insights from a diffusion tensor imaging study

Shin-Lei Peng1, Sheng-Min Huang2, and Chun-Chieh Chan1
1Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, 2Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan

Synopsis

Keywords: Gray Matter, Diffusion Tensor ImagingA critical step in animal diffusion tensor imaging (DTI) studies is the use of anesthetics. Understanding the influence of specific anesthesia regimes on DTI-derived parameters is imperative when comparing results between animal studies using different anesthetics. Here, the quantification of fractional anisotropy (FA) and mean diffusivity (MD) under different alpha-chloralose and isoflurane is discussed. The estimated MD under isoflurane anesthesia is higher than that under alpha-chloralose anesthesia. FA quantitation was also influenced by anesthesia regimens to varying extents, depending on the brain regions and b-values. In summary, both scanning parameters and the anesthesia regimens significantly impacted quantifications of DTI indices.

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