Abstract #3353

Non-exponential transverse relaxation in the brain’s basal ganglia

Rita Oliveira¹, Quentin Raynaud¹, Valerij Kiselev², Ileana Jelescu³, and Antoine Lutti¹

¹Laboratory for Research in Neuroimaging, Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ²Division of Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, ³Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland

Synopsis

Keywords: Gray Matter, RelaxometryNon-exponential transverse relaxation in the brain’s basal ganglia has been investigated in theoretical studies but little evidence from in-vivo MRI data exists in support of this behaviour. Here, we provide experimental observation of non-exponential transverse relaxation in-vivo MRI data in the basal ganglia at 3T. The strongest deviations from exponential behaviour take place in the iron-rich pallidum and substantia nigra. Our results suggest that water diffusion through the inhomogeneous magnetic field induced by paramagnetic iron deposits may be at the source of non-exponential transverse relaxation in the basal ganglia.

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