Meeting Banner
Abstract #3355

Time dependent diffusion and kurtosis of human brain metabolites

André Döring1, Frank Rösler2, Kadir Şimşek1,3, Maryam Afzali1,4, Roland Kreis5,6, Derek K Jones1, Julien Valette7, and Marco Palombo1,3
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 2Department of Mathematics, University of Bern, Bern, Switzerland, 3School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom, 4Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 5Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University Bern, Bern, Switzerland, 6Translational Imaging Center, sitem-insel, Bern, Switzerland, 7Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, Paris, France

Synopsis

Keywords: Gray Matter, Spectroscopy, Metabolites, Diffusion, ADC, Kurtosis, Morphology, Gray Matter, SpectroscopyThis work demonstrates that metabolites diffusion and kurtosis time-dependence can be measured in vivo in the human brain using Diffusion-Weighted MR Spectroscopy (DW-MRS) and ultra-strong gradients. At short diffusion-times, DW-MRS is sensitive to cytoplasmic viscosity and short-range structures; at long diffusion-times to long-range structures. We show that modeling the diffusion-time dependence of intracellular and cell-type specific metabolites can be used to infer brain cell morphology and recover fiber radii consistent with healthy human brain histology. Furthermore, we show that water diffusion at long diffusion-times is affected by exchange between intra- and extracellular compartment, which poses challenges for microstructural modeling.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords