Abstract #3361

QSM and edited MRS reveal altered deep-brain gray matter microstructure and neurometabolism in patients with hepatic encephalopathy

Helge J. Zöllner^1,2,3,4, Thomas A. Thiel^3,4, Markus S. Jördens⁵, Dieter Häussinger⁵, Georg Oeltzschner^1,2, Markus Butz³, Hans-Jörg Wittsack⁴, Alfons Schnitzler³, and Eric Bechler⁴

¹The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Kennedy Krieger Institute, F. M. Kirby Research Center for Functional Brain Imaging, Baltimore, MD, United States, ³Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany, ⁴Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany, ⁵Department of Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany

Synopsis

Keywords: Gray Matter, Quantitative Susceptibility mapping, Hepatic encephalopathyHepatic encephalopathy (HE) is a common neurological manifestation of liver cirrhosis characterized by altered brain microstructure and metabolism. Here, Quantitative Susceptibility Mapping (QSM) was performed in a well-characterized cohort of HE patients and correlated with metabolite estimates derived from GABA-edited MR spectroscopy. Deep-brain gray matter micro-susceptibility was significantly altered in the bilateral pallidum and dentate nuclei in HE patients. These results were closely linked to metabolite estimates and clinical metrics.

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