Abstract #3364

Cortical laminar specific microstructure and magnetic susceptibility in ex-vivo human brain

Zhiyong Zhao¹, Zuozhen Cao¹, Qinfeng Zhu¹, Liangying Zhu¹, Sihui Li¹, Keqing Zhu^2,3, Jing Zhang^2,3, and Dan Wu¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²China Brain Bank and Department of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, and Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China, ³Department of Pathology, The First Affiliated Hospital and School of Medicine, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Gray Matter, Ex-Vivo Applications, cortical laminae, microstructure, magnetic susceptibility, human brainAlthough recent high-resolution functional MRI studies have revealed laminar-specific cortical activity in the human brain, the underlying structural underpinning remains unclear. The present study collected submillimeter-resolution MR images from 10 ex-vivo human hemispheres. We computed the microstructural metrics and magnetic susceptibility for each sample at different cortical depths. We found that the cortical microstructure and magnetic susceptibility showed a depth-dependent pattern, which varied in different cortical regions. The cortical profiles were then correlated with cell density and myelin content obtained from histological staining. These findings may help to understand the structural basis of laminar brain function.

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