Abstract #3365

Analyzing Cortical Thickness and Volume in patients with Sickle Cell Disease using 7T-MRI

Sharadhi Umesh Bharadwaj¹, Tales Santini², Joel D.K Disu¹, Busola Oluwole³, Enrico M. Novelli^4,5,6, Tamer S Ibrahim^7,8,9, and Sossena Wood^1,10

¹Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States, ²University of Pittsburgh, Pittsburgh, PA, United States, ³University of Washington/Fred Hutch, Seattle, WA, United States, ⁴Vascular Medicine Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, ⁵Department of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, ⁶Sickle Cell Center of Excellence, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, ⁷Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ⁸Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States, ⁹Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States, ¹⁰Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, United States

Synopsis

Keywords: Gray Matter, High-Field MRI, Sickle cell disease, cortical thickness, cortical volumeThe study compares cortical thickness and volume between patients with Sickle Cell Disease (SCD) and healthy controls (HC). There were no significant differences in the cortical thickness and volume of the whole brain between HC and patients with SCD. We found significant differences (p<0.05) in the temporal and parietal regions between HC and patients with SCD. We found significant differences in the parietal and frontal lobes between severe SCD (HbSS) and HC. Between patients with mild SCD (HbSC and HbSβ+thalassemia) and HC, significant differences in cortical thickness in the inferior parietal and lateral occipital regions were found.

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