Abstract #3367

Investigating Regional Changes in Brain Magnetic Susceptibility in Tanzanian Children with Sickle Cell Anaemia at 1.5 Tesla

Mitchel Lee¹, Russell Murdoch^1,2, Mboka Jakob³, Fenella Kirkham², and Karin Shmueli¹

¹Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²Imaging and Biophysics, Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom, ³Department of Radiology & Imaging, Muhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania

Synopsis

Keywords: Gray Matter, Susceptibility

Although sickle cell anaemia (SCA) affects the brain, causing stroke and neurocognitive complications, its pathophysiological mechanisms are poorly understood. Quantitative Susceptibility Mapping (QSM) reveals alterations in tissue composition. Therefore, we applied QSM to investigate changes in brain susceptibility in 168 SCA patients compared to 47 healthy controls scanned at 1.5 Tesla in Tanzania. We found a significant susceptibility decrease in SCA vs. controls in the caudate nucleus and globus pallidus and a significant increase in susceptibility in the red nucleus and dentate. Blood haemoglobin levels had a significant positive correlation with susceptibility in the globus pallidus, caudate nucleus and putamen.

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