Keywords: Gray Matter, Aging, menopauseAmong recent voxel based-morphometry (VBM) technique, DARTEL (Diffeomorphic Anatomical Registration Through Exponentiated Lie Algebra)-based VBM method can provide powerful information to understanding morphologic variations in whole brain areas. In women, several VBM studies reported unveiling the brain morphologic reductions (putamen, pallidum, hippocampus, postcentral gyrus, frontal/paritetal/temporal gyrus, and so on) after menopause. These studies provided menopause-related brain centers in postmenopausal women; however these morphologic findings might be included potentially case-sensitive results as a consequence of the enrolled population. This study was performed a multicentric study to evaluate cerebral morphological changes in menopausal women by using a DARTEL-based VBM method.
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