Abstract #3369

Differential Gray Matter Volume Loss in Controlled and Uncontrolled Type 2 Diabetes Mellitus Over Time

Bhaswati Roy¹, Sarah E. Choi², Matthew J. Freeby³, and Rajesh Kumar^1,4,5,6

¹Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States, ²UCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, United States, ³Medicine, University of California Los Angeles, Los Angeles, CA, United States, ⁴Radiology, University of California Los Angeles, Los Angeles, CA, United States, ⁵Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, ⁶Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Gray Matter, DiabetesPatients with Type 2 diabetes mellitus (T2DM) show brain tissue changes in mood and cognitive control sites, functions that are deficient in the condition. However, the extent of brain gray matter volume loss in various sites, as well as progression of volume loss with time in controlled and uncontrolled T2DM adults are unclear. We observed higher gray matter volume loss in crucial brain areas involved in cognition and mood control in T2DM adults with uncontrolled glucose levels and accelerated progression after 6-months of follow-up. These findings indicate the need for optimal glucose management in T2DM adults.

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