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Abstract #3372

Associations of white matter connections with neurocognitive development in healthy children

Rajikha Raja1, Ruitian Song1, John Glass1, and Wilburn E Reddick1
1Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN, United States

Synopsis

Keywords: Brain Connectivity, Normal development, ConnectomeWe investigated the associations between structural connectivity and neurocognitive development in healthy children using MRI and behavioral data from 42 subjects belonging to Lifespan Human Connectome Project Development dataset. Diffusion MRI data were analysed using multi-shell multi-tissue constrained spherical deconvolution model to compute fiber orientation distribution functions before probabilistic fiber tracking was performed to obtain whole brain tractograms. Connectivity matrices were computed based on streamline density using nodes from HCP-MMP1 parcellation. Multiple significant correlations between connectivity and cognitive scores measuring working memory, processing speed and executive functioning were identified in this study.

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Keywords