Keywords: Multiple Sclerosis, Brain Connectivity, Myelination integrity, cognitive impairmentImpairment of higher-order cognition is a difficult aspect of MS pathology that poses a long-standing challenge for patient care advancement. Understanding how myelination integrity in the cingulum network – a brain pathway implicated in cognition – is related to lost or preserved cognitive functions is fundamental to enable comprehensive MS care and personalized remyelination therapeutics. We investigated if myelination integrity data has the potential to aid in characterizing individual differences in information processing in MS patients. Our findings support that myelination structure-function measured by SHIFT MRI is elucidatory variable to describe individual differences in higher-order cognitive function in MS patients.
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