Abstract #3379

Hyperperfusion precedes demyelination in Multiple Sclerosis lesion formation : a multimodal MRI and [11C]-PiB PET study

Théodore Soulier¹, Emanuele Morena², Arya Yazdan Panah³, Matteo Tonietto⁴, Mariem Hamzaoui⁵, Vito Ricigliano⁶, Giacomo Boffa⁵, Michel Bottlaender⁷, Benedetta Bodini⁸, and Bruno Stankoff⁸

¹Institut du Cerveau (ICM) = Paris Brain Institute - Sorbonne Université, Paris, France, ²Sapienza University of Rome, Rome, Italy, ³Paris Brain Institute - Sorbonne Université - INRIA, Paris, France, ⁴Centre Hospitalier Frédéric Joliot - CEA, Orsay, France, ⁵Paris Brain Institute - Sorbonne Université, Paris, France, ⁶Paris Brain Institute - Sorbonne Université - Hôpital Pitié Salpêtrière APHP, Paris, France, ⁷Centre Hospitalier Frédéric Joliot - CEA - Université Paris Saclay, Orsay, France, ⁸Paris Brain Institute - Sorbonne Université - CNRS - INSERM - Hôpital Saint Antoine APHP, Paris, France

Synopsis

Keywords: Multiple Sclerosis, PET/MR, Prelesions, lesion formationStudying prelesions, the healthy areas preceding lesion appearance, helps to understand the Multiple Sclerosis (MS) lesion formation process. We study here prelesions in a longitudinal cohort of 19 MS patients combining MRI with Positron Emission Tomography (PET). MRI allowed to identify prelesions, whereas [11C]-PiB PET allowed to quantify myelin content as well as perfusion. We found that the 69 analyzable prelesions of our cohort were heterogeneous regarding perfusion: 24.6% were hyperperfused and 18.8% hypoperfused. Hypoperfused prelesions showed multimodal evidence of demyelination whereas hyperperfused prelesions were not demyelinated yet, suggesting that hyperperfusion precedes demyelination in the MS lesion formation process.

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