Abstract #3387

Improved Characterization of White Matter in Multiple Sclerosis with Free Water-Corrected Diffusion MRI

Samantha By¹, Jean-Christophe Houde², Chahin Pachai¹, Loika Maltais², Jorge A. Torres³, Gabrielle Grenier², Sujuan Huang⁴, and Daniel P. Bradley³

¹Bristol Myers Squibb, Lawrenceville, NJ, United States, ²Imeka Solutions, Inc., Sherbrooke, QC, Canada, ³Biogen, Cambridge, MA, United States, ⁴Cytel, Waltham, MA, United States

Synopsis

Keywords: Multiple Sclerosis, Diffusion/other diffusion imaging techniquesFree water (FW)-corrected metrics in diffusion MRI have shown promise in elucidating confounding pathological processes in multiple sclerosis (MS). Here, we present a retrospective analysis of FW-corrected diffusion in a cohort of 287 MS participants from a multi-center clinical trial. Our preliminary results indicate the method’s ability to distinguish different lesion types and MS subtypes.

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