Abstract #3392

Comparison of a hybrid multi-delay pseudo-continuous arterial spin labelling scheme with time-encoded and variable-TR schemes

Makoto Obara¹, Osamu Togao², Lena Vaclavu³, Ryoji Mikayama⁴, Tatsuhiro Wada⁴, Shota Ishida⁵, Hiroshi Hamano¹, Matthias J.P. van Osch³, Kim van de Ven⁶, Yu Ueda¹, Jihun Kwon¹, Masami Yoneyama¹, and Marc Van Cauteren⁷

¹Philips Japan, Tokyo, Japan, ²Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ³C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Division of Radiology, Department of Medical Technology, Kyushu University, Fukuoka, Japan, ⁵Department of Radiological Technology, Faculty of medical sciences, Kyoto College of Medical Science, Kyoto, Japan, ⁶Philips Healthcare, Best, Netherlands, ⁷Philips Healthcare, Tokyo, Japan

Synopsis

Keywords: Quantitative Imaging, Perfusion, ASLTo accurately calculate cerebral blood flow (CBF) and arterial transit time (ATT), there are two kinds of time-efficient approaches in use for multi-delay pseudo-continuous arterial spin labelling: time-encoded and sequential variable-TR. Hybrid schemes have recently been proposed that exploit the strengths of these approaches, but they have not been evaluated head-to-head, and the purpose of this study is therefore to investigate the clinical validity of hybrid schemes. The SNR, CBF and ATT were measured and compared in seven healthy subjects. A higher SNR was obtained in the hybrid scheme with high correlation coefficients with other ATT schemes, suggesting quantitative ability.

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