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Abstract #3393

Mapping changes in tissue 23Na concentration and cerebral blood flow during a visual task using ASL and functional Sodium Imaging (fNaI)

Iris Asllani1,2, Balázs Örzsik1, Samira Bouyagoub1, Joseph Woods3, Itamar Ronen1, Guillaume Madelin4, and Mara Cercignani5
1University of Sussex, Brighton, United Kingdom, 2Rochester Institute of Technology, Rochester, NY, United States, 3University of Oxford, Oxford, United Kingdom, 4New York University, New York, NY, United States, 5Cardiff University, Cardiff, United Kingdom

Synopsis

Keywords: Quantitative Imaging, Neuro, Sodium MRI, fMRI, Arterial Spin Labeling, Partial Volume CorrectionSodium MRI was combined with arterial spin labeling (ASL) perfusion MRI to detect changes in total sodium concentration (TSC) and cerebral blood flow (CBF) associated with visual tast activation on 6 healthy volunteers. There was no overlap between the areas in the visual cortex where there was a significant change in CBF (~38%) and the regions where a change (~11%) in TSC was detected. Results from partial volume correction indicate that most of the changes in TSC originated in the white matter.

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Keywords