Keywords: Quantitative Imaging, DSC & DCE Perfusion, Cancer, Orthotopic, 4T1, MetronomicMetronomic chemotherapy (MCT) is a cost-effective combinatorial treatment that can be used to normalize tumor vasculature for further treatment. Current monitoring schemes of MCT response are either invasive or are partially sampled. Dynamic contrast enhanced (DCE)-MRI can be utilized to measure the spatial heterogeneity of the tumor microenvironment which can serve as a noninvasive biomarker for treatment response. Using an MCT dose scheme of cyclophosphamide (70mg/kgx3 IP/week), the preliminary result shows that the DCE-MRI can detect the tumor vascular normalization in the treated group.
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