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Abstract #3395

Monitoring metronomic chemotherapy response in orthotopic breast cancer mouse model using DCE-MRI

Sawwal Qayyum1, Jin Zhang1, and Gene Kim1
1Radiology, Weill Cornell Medical, New York City, NY, United States

Synopsis

Keywords: Quantitative Imaging, DSC & DCE Perfusion, Cancer, Orthotopic, 4T1, MetronomicMetronomic chemotherapy (MCT) is a cost-effective combinatorial treatment that can be used to normalize tumor vasculature for further treatment. Current monitoring schemes of MCT response are either invasive or are partially sampled. Dynamic contrast enhanced (DCE)-MRI can be utilized to measure the spatial heterogeneity of the tumor microenvironment which can serve as a noninvasive biomarker for treatment response. Using an MCT dose scheme of cyclophosphamide (70mg/kgx3 IP/week), the preliminary result shows that the DCE-MRI can detect the tumor vascular normalization in the treated group.

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