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Abstract #3401

Automating Component Selection in Independent Component Analysis (ICA) in dynamic Oxygen-Enhanced MRI (dOE-MRI)

Annika Hofmann1,2, Jennifer H.E. Baker3, Firas Moosvi4, and Stefan A Reinsberg2
1Department of Physics, TU Dortmund University, Dortmund, Germany, 2Department of Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 3Radiation Biology Unit, British Columbia Cancer Research Centre, Vancouver, BC, Canada, 4Department of Computer Science, Mathematics, Physics and Statistics, University of British Columbia, Kelowna, BC, Canada

Synopsis

Keywords: Quantitative Imaging, Cancer, Independent Component AnalysisUsing Independent Component Analysis (ICA) in dynamic Oxygen-Enhanced MRI has been shown to improve the sensitivity of this technique. However, the ICA component has to be identified manually by an observer. In this work we propose an optimization process that automatically determines the best number of components and extracts the component in best accordance to the target function of the breathing challenge.

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