Abstract #3405

Stepwise validation of Perfusion MRI Kinetic Modeling using an Extracorporeal Circulation for AIF determination in Mice

Florian Gierse¹, Florian Büther², Juela Cufe², Bastian Maus³, Michael Claesener², Sven Hermann¹, Klaus Peter Schäfers¹, Katharina Kronenberg⁴, Uwe Karst⁴, Michael Andreas Schäfers¹, Cornelius Faber³, and Philipp Backhaus²

¹European Institute for Molecular Imaging, University of Münster, Münster, Germany, ²Department for Nuclear Medicine, University Hospital Münster, Münster, Germany, ³Translational Research Imaging Center, Clinic of Radiology, University of Münster, Münster, Germany, ⁴Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany

Synopsis

Keywords: Quantitative Imaging, PerfusionCalculation of perfusion parameters from DCE-MRI using pharmacokinetic modeling depends on accurate determination of the dynamic tissue concentration and the dynamic arterial blood concentration (AIF). However, precise AIFs are difficult to measure in small animals. We introduce a novel extracorporeal circulation approach from the external carotid artery for feasible AIF determination. DCE derived AIF and tissue contrast agent concentrations corresponded well with radioactive analogs and mass spectrometry. Perfusion parameters derived by different pharmacokinetic models demonstrated variable agreement with simultaneous radiotracer derived calculations of modeling parameters. Overall, we introduce an accurate and precise framework for quantitative perfusion MRI in small animals.

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