Abstract #3408

Magnetic Ferritin Nanoprobe Imaging Analysis with MRI Slow Velocity Mapping Measurement

FangFei He^1,2, Wentao Liu², Tongwei Zhang³, Fan Yang⁴, Yi Hou¹, Zhihua Gan¹, and Dong Han^2,5

¹College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China, ²CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, China, ³Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, China, ⁴Beijing Intelligent Brain Cloud Inc, Beijing, China, ⁵University of Chinese Academy of Sciences, Beijing, China

Synopsis

Keywords: Quantitative Imaging, Velocity & Flow, Tumor Interstitial FluidFor effectively penetrating into tumors, drug diffusion speed should be greater than the outward tumor interstitial fluid (TIF) convection speed. Studying TIF is helpful to deeply understand the fluid behavior of tumor fluid flow and its impact on the delivery of nano drugs. In this experiment, an improved PC-MRI slow flow measurement sequence was used to detect the velocity of interstitial fluid in different tumor growth periods. Combined with clinical standard sequence, the relationship between the distribution of the magnetic ferritin (M-HFn) contrast agent in tumor and the velocity of TIF was observed and analyzed.

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