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Abstract #3416

Effect of chemical shift displacement on Lipid Composition determination in localized 1H NMR Spectroscopy

Julian Mevenkamp1,2, Mijke Buitinga1,2, Pandichelvam Veeraiah3,4, and Vera B. Schrauwen-Hinderling1,2,5
1Nutrition & Movement Sciences, Maastricht University, Maastricht, Netherlands, 2Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 3Scannexus, Maastricht, Netherlands, 4Faculty of Health Medicine & Life Sciences, Maastricht University, Maastricht, Netherlands, 5German Diabetes Center, Düsseldorf, Germany

Synopsis

Keywords: Artifacts, Spectroscopy, Chemical Shift DisplacementWe showed that implementing prior knowledge about Chemical Shift Displacement Artifacts (CSDA) in localized MR-spectroscopy improves fit quality in the context of hepatic lipid composition measurements (LICO) performed with PRESS. Residuals of fitting PRESS spectra of peanut oil with CSDA prior knowledge show smaller residuals compared to assuming a purely Spin Echo based J-coupling evolution during the echo time. Furthermore, peanut oil LICO measured by PRESS and fitted with CSDA prior knowledge almost matched reference values determined by HR-NMR (PUFAHR-NMR = 23.5%, MUFAHR-NMR = 52.9%, SFAHR-NMR = 23.6% vs. PUFACSDA = 21.57%, MUFACSDA = 54.4%, SFACSDA = 24.0%).

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Keywords