Abstract #3431

Association of Ki-67 With Metabolite and Lipid Levels in High Grade Breast Cancer Patients based on Correlated MR Spectroscopic Imaging and Biopsy

Ajin Joy¹, Andres Saucedo¹, Melissa Joines¹, Stephanie Lee-Felker¹, Manoj K Sarma¹, James Sayre¹, Maggie Dinome², and M. Albert Thomas¹

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Surgery, University of California, Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Data Analysis, BreastFive-dimensional (5D) echo-planar correlated spectroscopic imaging (EP-COSI) combines 2 spectral and 3 spatial dimensions to record two dimensional (2D) correlated spectroscopy (COSY) spectra in multiple regions in multiple slices. In this study, multiple 2D COSY spectra were recorded from breast cancer patients by 5D EP-COSI within practical scan time durations using non-uniform undersampling of one spectral and two spatial dimensions, and compressed sensing-based reconstruction. Different metabolite and lipid ratios were quantified and its association with Ki-67 metric was studied. Findings of this study showed statistically significant association of metabolite and lipid levels with Ki-67 measures in breast cancer patients.

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