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Abstract #3432

Glutamate Predicts Post-Concussion Symptoms in Collegiate Athletes

Annelise Lemaire1,2, Hui Jun Liao1, Inga Koerte3, David Howell4, Alexander Lin1,5, and Katherine Breedlove1,5
1Brigham and Women’s Hospital, Boston, MA, United States, 2University of Michigan, Ann Arbor, MI, United States, 3Ludwig-Maximilians-Universitat, Munich, Germany, 4University of Colorado-Anschutz, Aurora, CO, United States, 5Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Data Analysis, Contrast Mechanisms, Traumatic Brain InjuryA population of collegiate athletes, along with matched age and gender-matched student-athlete controls, were evaluated post-concussion, for neurometabolic levels in the PCG by magnetic resonance spectroscopy (MRS) and Post-Concussion Symptom Scale (PCSS) following injury. Evaluations were conducted 72 hours post-diagnosis. For the purpose of this work, correlations between total Glutamate (Glu+Gln), total Glutamate to total Creatine ratios, and symptoms on the PCS scale associated with cognitive fatigue - such as mental fog, drowsiness, fatigue, and feeling slowed - were explored.

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Keywords