Abstract #3437

The Influence of the MT effect on the Accuracy of T1 Quantification by the Dual Flip Angle Method

Zhen Hu¹, Dan Zhu^2,3, and Qin Qin^2,3

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Kirby Center, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Signal Modeling, Brain, RelaxometryThe dual flip angle (DFA) method is widely used for brain T1 quantification. In addition to the well-known RF field effect, this study investigated the overlooked magnetization transfer (MT) effect for the accuracy of in-vivo T1 mapping. Based on the two-pool Bloch simulation, the DFA derived T1 estimation revealed FA and TR dependence, which was confirmed by the in-vivo brain T1 mapping using the same set of sequence parameters. Longer TR (30 ms) reduced the variation between FA pairs and were closer to the literature values, but at the cost of longer acquisition time.

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