Keywords: Data Analysis, Spectroscopy, brain, phosphocholine, phosphoethanolamine, phosphomonoesterIt has been a common practice to quantify brain phosphomonoester (PME) 31P signals using a two-component model composed of phosphoethanolamine (PE) and phosphocholine (PC). This study demonstrates spectral evidence of the presence of a hidden broad PME (h-PME) signal underneath PE and PC resonances, characterized by a short T1 and potentially contributed by RBC 2,3-DPG in brain blood vessels, though other sources of signal contribution cannot be fully ruled out. The results have implication in using PE and PC as biomarkers of altered phospholipid metabolism in brain pathologies.
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