Abstract #3445

Grading and assessment of intra-tumor heterogeneity of gliomas using 3D CEST imaging with compressed sensing and sensitivity encoding

Tatsuhiro Wada^1,2, Osamu Togao³, Chiaki Tokunaga¹, Kazufumi Kikuchi⁴, Koji Yamashita⁵, Masami Yoneyama⁶, Masahiro Oga¹, Koji Kobayashi¹, Toyoyuki Kato¹, Kousei Ishigami⁴, and Hidetake Yabuuchi⁷

¹Division of Radiology, Department of Medical Technology, Kyushu university hospital, Fukuoka, Japan, ²Department of Health Sciences, Graduate school of Medical Sciences, Kyushu University, Fukuoka, Japan, ³Department of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ⁴Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ⁵Department of Radiology Informatics & Network, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ⁶Philips Japan, Tokyo, Japan, ⁷Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan

Synopsis

Keywords: Tumors, CEST & MTGlioma grading using chemical exchange saturation transfer (CEST) imaging is often performed in a single cross-section. However, CEST imaging of multiple cross-sections is desirable for intra-tumor heterogeneity. Compressed sensing and sensitivity encoding (CS-SENSE) was applied to CEST imaging to obtain multi-slice CEST imaging in a clinically appropriate scan time. The diagnostic performance of three-dimensional (3D) CEST imaging was comparable to that of a two-dimensional CEST imaging. The evaluation of the entire tumors by multi-slice CEST imaging was important in the gliomas' grading because the signal intensities differed among the tumor slices.

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