Abstract #3446

Theoretical justification for fluid-suppressed APTw imaging based on spillover correction principles

Maria Sedykh¹, Stefano Casagranda², Patrick Liebig³, Christos Papageorgakis², Laura Mancini^4,5, Sotirios Bisdas^4,5, Manuel Schmidt¹, Arnd Doerfler¹, and Moritz Zaiss¹

¹Institut of Neuroradiology, University Clinic Erlangen, Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany, ²Department of R&D Advanced Applications, Olea Medical, La Ciotat, France, ³Siemens Healthcare GmbH, Erlangen, Germany, ⁴Lysholm Department of Neuroradiology, University College of London Hospitals NHS Foundation Trust, London, United Kingdom, ⁵Institute of Neurology UCL, London, United Kingdom

Synopsis

Keywords: Tumors, CEST & MTFluid suppression has an inestimable value in improving the readability of Amide Proton Transfer weighted imaging in the neuro-oncological field, by removing contamination effects in the fluid compartments. With this work we wanted to justify the derivation of this metric and to show different clinical examples. Our new fluid-suppressed APTw metric for 3T MR imaging, based on the principles of Spillover Correction for CEST imaging, can be then derived through the Bloch McConnell Equations.

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