Abstract #3447

Amide proton transfer weighted (APTw) imaging-based radiomics in the molecular subtypes prediction and grading of adult-type diffuse gliomas

Minghao Wu¹, Tongling Jiang², Cong Xie³, Xianchang Zhang⁴, Yi Zhang⁵, and Yaou Liu¹

¹Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, beijing, China, ²Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China, Hangzhou, China, ³Beijing Tiantan Hospital, Capital Medical University, Beijing, China, beijing, China, ⁴MR Collaboration, Siemens Healthineers Ltd., Beijing, China, beijing, China, ⁵College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China, Hangzhou, China

Synopsis

Keywords: Radiomics, Brain, amide proton transfer weighted (APTw) imagingThe fifth edition of the 2021 WHO Classification of Tumors of the Central Nervous System (WHO CNS5) has introduced significant changes in classifying glioma subtypes based on molecular profiles. This study investigated the feasibility of amide proton transfer weighted (APTw)-based radiomics for predicting molecular subtypes and WHO grade of adult-type diffuse gliomas. APTw-based radiomics achieved satisfactory performance in distinguishing three molecular subtypes and WHO grade (High (Ⅳ grade)/Low (Ⅱ-Ⅲ grade)). This application may be an effective and promising quantitative approach for better noninvasive characterization and classification of gliomas.

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