Abstract #3448

A Multicenter Study of Cervical Cancer using Dynamic Contrast-Enhanced MRI: Are Measurements of Quantitative Imaging Reproducible in Clinic?

Xue Wang¹, Shujian Li², Zhijun Ye³, Tang-San Koh⁴, Zujun Hou⁵, Zhihan Yan¹, and Lu Han⁶

¹The Second Affiliated Hospital and Yuying Children′s Hospital of Wenzhou Medical University, Wenzhou, China, ²The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ³The Second Affiliated Hospital of Sichuan University, Chengdu, China, ⁴National Cancer Center, Singapore, Singapore, Singapore, ⁵Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China, ⁶Philips Healthcare, Shanghai, Shanghai, China

Synopsis

Keywords: Uterus, Reproductive, Dynamic Contrast-Enhanced ImagingBy comparing the distributions of measured DCE kinetic parameters in cervical cancer tissue by three MRI scanners in different clinical centers. It was demonstrated that (i) Each of the three scanners consistently showed similar findings on the characterization of cervical cancer microenvironment. (ii) The difference in MRI3 stemmed from keyhole imaging in the DCE protocol which could lead to underestimation of concentration of contrast media in viable tumor region. (iii) The close distribution between MRI1 and MRI2 indicated that consistent DCE quantitative metrics could be attained in scanners from different vendors if imaging protocol and data postprocessing could be standardized.

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