Abstract #3456

Peri-tumoural lipid composition mapping of the breast for early response to neoadjuvant chemotherapy using chemical shift-encoded imaging

Sai Man Cheung¹, Kwok-Shing Chan², Nicholas Senn¹, Ravi Sharma³, Trevor McGoldrick³, Tanja Gagliardi^1,4, Ehab Husain⁵, Yazan Masannat⁶, and Jiabao He^1,7

¹Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom, ²Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, ³Department of Oncology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, ⁴Department of Radiology, Royal Marsden Hospital, London, United Kingdom, ⁵Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, ⁶Breast Unit, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, ⁷Translational and Clinical Research Institute, Newcastle University, Aberdeen, United Kingdom

Synopsis

Keywords: Breast, FatPeri-tumoural lipid composition plays a major role in the disease progression of breast cancer, and novel chemical shift-encoded imaging (CSEI) allows rapid lipid mapping of the whole breast. We have previously observed an imbalance of peri-tumoural lipid composition in postmenopausal women with breast cancer using CSEI. Monitoring of lipid composition for early sign of tumour regression might be crucial for an accurate differentiation of patients responding to neoadjuvant chemotherapy (NACT). We hence set out to elucidate the longitudinal change in lipid composition in the peri-tumoural region and the whole breast in patients with breast cancer using CSEI.

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