Abstract #3458

Breast MRI during neoadjuvant endocrine therapy for patients with estrogen-receptor positive/HER2 negative breast cancer

Natsuko Onishi¹, Jessica E Gibbs¹, Ella F Jones¹, Teffany Joy Bareng¹, Jiachao Liang¹, Julia Carmona-Bozo¹, Wen Li¹, David C Newitt¹, Kimberly M Ray¹, Courtney Lawhn Heath¹, Rita Mukhtar², Bonnie N Joe¹, the I-SPY 2 Investigator Network³, the I-SPY 2 Imaging Working Group¹, Laura J Esserman ², A. Jo Chien⁴, and Nola M Hylton¹

¹Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Surgery, University of California, San Francisco, San Francisco, CA, United States, ³Quantum Leap Healthcare Collaborative, San Francisco, CA, United States, ⁴Department of Medicine, University of California, San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Breast, CancerThis study aimed to investigate the longitudinal changes in functional tumor volume (FTV) and background parenchymal enhancement (BPE) derived from dynamic contrast-enhanced breast MRI during neoadjuvant endocrine therapy (NET). For comparison, we also evaluated a similar cohort of patients who received standard neoadjuvant chemotherapy (NAC). Similar to the NAC cohort, the NET cohort showed early changes in FTV and BPE as early as three weeks of treatment. In the NET cohort, early BPE decrease was prominent especially for patients with higher baseline BPE and premenopausal patients. These finding illustrate the potential of MRI metrics as early imaging biomarkers for NET.

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