Abstract #3460

Early parenchymal changes on MRI and fluoroestradiol db-PET during neoadjuvant endocrine therapy in patients with ER +/HER2- breast cancer

Julia Carlota Carmona¹, Natsuko Onishi², Jiachao Liang², Jessica Gibbs², Ella Jones³, Teffany Joy Bareng², Wen Li², David Newitt², Kim Ray², Courtney Lawhn¹, Bonnie Joe², Rita Mukhtar², I-SPY 2 Network², ISPY 2 Imaging Working group², Laura Esserman², Jo Chien², and Nola Hylton²

¹Radiology, UCSF, San Francisco, CA, United States, ²UCSF, San Francisco, CA, United States, ³NIH, San Francisco, CA, United States

Synopsis

Keywords: Breast, Cancer, MRI, fluoroestradiol, PET, endocrine, therapyThe aim of our study was to assess early parenchymal changes during neoadjuvant endocrine therapy (NET) using both DCE-MRI and dedicated breast PET with [18F]-fluoroestradiol (FES-dbPET). We investigated background parenchymal enhancement (BPE) on MRI and background parenchymal uptake on FES-dbPET for seventeen patients with ER+/HER2- breast cancers. Statistically significant decrease in BPE was shown after 3 weeks of NET. Estimated SUVs (mean, max and peak) were lower after 3 weeks of NET, although the difference did not reach statistical significance. Our results illustrate the potential of DCE-MRI and FES-dbPET to detect early change in breast parenchyma during NET.

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