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Abstract #3475

Improved Assessment of Brain Tissue Viability in Acute Stroke Using Fast High-Resolution 3D-MRSI and Quantitative T2 Imaging

Ziyu Meng1, Tianyao Wang2, Bin Bo1, Yibo Zhao3,4, Yudu Li3,5, Rong Guo3,6, Wen Jin3,4, Xin Yu7, Zhi-Pei Liang3,4, and Yao Li1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Radiology Department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 6Siemens Medical Solutions USA, Inc, Urbana, IL, United States, 7Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Synopsis

Keywords: Stroke, StrokeAccurate assessment of tissue viability is of great importance for the design of therapeutic interventions in acute stroke. 1H-MRSI and quantitative T2 imaging can provide neurochemical biomarkers sensitive to the pathological changes in stroke but their applications have been limited by long scan times. This study introduces a novel approach that combines fast high-resolution 3D-MRSI with quantitative T2 imaging to assess the viability of ischemic tissues in acute stroke. This approach achieved improved discrimination between ischemic brain tissues that ultimately infarcted and those recovered using joint neurometabolite concentrations and quantitative T2 values, in comparison with classical DWI and PWI methods.

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Abstract Presentation Video

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