Abstract #3479

Altered Glx and APT values in hippocampus of patients with aMCI: a novel combined imaging diagnostic marker

Xin Chen^1,2, Tao Gong¹, Tong Chen³, Changyuan Xu¹, Yuchao Li¹, Qingxu Song⁴, Liangjie lin⁵, Georg Oeltzschner^6,7, Richard A. E. Edden⁶, Guangbin Wang¹, and Zhangyong Xia²

¹Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ²Liaocheng People’s Hospital, Liaocheng, China, ³Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China, ⁴Qilu Hospital of Shandong University, Jinan, China, ⁵Philips Healthcare, Beijing, China, ⁶The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Alzheimer's Disease, Brain, Amnestic mild cognitive impairment; hippocampus; MEGA-PRESS; amide proton transfer-weighted imaging; imaging diagnostic markerAmnestic mild cognitive impairment (aMCI) is considered as a prodromal stage of Alzheimer's disease (AD). Growing evidence supports the hypothesis that unbalanced excitatory/inhibitory (glutamate and gamma-aminobutyric acid) neurotransmitters and consequent abnormal protein deposition in hippocampus contribute to the pathological process of MCI and AD. We explored the changes of hippocampal Glx/GABA+ levels and APTw in aMCI patients using MEGA-PRESS and APTw imaging. Patients with aMCI exhibited decreased Glx levels (and Glx/GABA+ ratios) and increased APTw values in hippocampus. The combination of Glx and APTw values improved the diagnostic performance for aMCI, suggesting it was a potential imaging diagnostic marker.

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