Abstract #3480

4D CSF flowmetry to map brain-wide slow CSF flow dynamics and patterns in subarachnoid space

Zijing Dong^1,2, Fuyixue Wang^1,2, Amelia K. Strom^1,3, Korbinian Eckstein⁴, Beata Bachrata⁴, Simon D. Robinson⁴, Bruce R. Rosen^1,2,3, Lawrence L. Wald^1,2,3, Laura D. Lewis⁵, and Jonathan R. Polimeni^1,2,3

¹Athinoula A. Martinos Center for Biomedical Imaging, MGH, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Charlestown, MA, United States, ³Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, ⁴High Field MR Centre, Medical University of Vienna, Vienna, Austria, ⁵Department of Biomedical Engineering, Boston University, Cambridge, MA, United States

Synopsis

Keywords: Neurofluids, BrainCerebrospinal fluid (CSF) flow is a key component of the brain’s waste clearance system. However, little is known about the brain-wide CSF flow in subarachnoid space (SAS), due to the low sensitivity of MRI-based flow imaging methods for measuring slow flow. Here, we proposed a phase-contrast 4D CSF flowmetry method using a pulsed-gradient-spin-echo EPI sequence, providing high sensitivity and efficiency to measure brain-wide slow CSF flow dynamics in SAS. Whole-brain CSF flow dynamics including velocity and direction changes were measured and our preliminary data suggest that both cardiac pulsation and respiration can drive CSF flow in both ventricles and SAS.

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