Abstract #3481

Reproducibility of quantitative 1H-decoupled, NOE-enhanced 31P-MRS in the human brain at 3 T.

Magnus Svensen¹, Christian Dölle², Njål Brekke³, Heidi Espeland⁴, Nora Tvedten⁴, John Georg Seland⁴, Frank Riemer⁵, and Charalampos Tzoulis⁶

¹Neuro-SysMed & Mohn Medical Imaging- and Visualization Center (MMIV), Bergen, Norway, ²Neuro-SysMed & University of Bergen, Bergen, Norway, ³Haukeland University Hospital, Bergen, Norway, ⁴University of Bergen, Bergen, Norway, ⁵Mohn Medical Imaging- and Visualization Center (MMIV), Bergen, Norway, ⁶Neuro-SysMed & University of Bergen & Haukeland University Hospital, Bergen, Norway

Synopsis

Keywords: Data Analysis, Spectroscopy, 31P1H-decoupled NOE-enhanced 31P-MRS has promising applications in the diagnosis and stratification of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and amytrophic lateral sclerosis (ALS) due to its ability to longitudinally and noninvasively measure changes to cell metabolism and energy conversion, which is heavily involved in these diseases. To aid clinical translation, this study focuses on assessing the reproducibility of 1H-decoupled NOE-enhanced 31P-MRS by measuring the resonances of metabolites involved in neural energy metabolism.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.