Abstract #3484

Toward a detailed subject-specific cerebrovascular model using Arterial Spin Labeling (ASL) Magnetic Resonance Imaging (MRI)

Alireza Sharifzadeh-Kermani¹, Finbar Argus¹, Jiantao Shen¹, Sarah-Jane Guild², David Dubowitz², Miriam Scadeng^2,3, Paul Condron³, Eryn Kwon^1,2,3, Samantha Holdsworth^2,3, Gonzalo Daniel Maso Talou¹, and Soroush Safaei¹

¹Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand, ²Faculty of Medical and Health Sciences & Centre for Brain Research, The University of Auckland, Auckland, New Zealand, ³Mātai Medical Research Institute, Tairāwhiti-Gisborne, New Zealand

Synopsis

Keywords: Blood vessels, Modelling, Arterial Spin Labeling, ASL, cerebral perfusion, CBF, 4D flow, blood flowComputed flows via haemodynamic models highly depend on peripheral resistances that affect the blood perfusion. To this end, finding a way to estimate these resistances is crucial for having a subject-specific model. Perfusion (CBF) maps produced by Arterial Spin Labeling (ASL)-MRI provide valuable information via which the model can be personalized. This new approach may be promising for providing blood flow measurements of the brain from ASL-CBF data in the absence of a full brain 4D flow sequence.

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