Abstract #3485

Altered neurovascular coupling in patients with MELAS evaluated by combining cerebral blood flow and regional homogeneity

Rong Wang¹, Yuxin Li¹, Jie Lin¹, Yong Zhang², and Jiankun Dai³

¹Huashan Hospital, Shanghai, China, ²GE Healthcare, Shanghai, China, Shanghai, China, ³MR Research, GE Healthcare, Beijing, China, Shanghai, China

Synopsis

Keywords: Stroke, fMRI (resting state)This is the first study that used a combined arterial spin labeling (ASL) and resting-state fMRI approach to assess the neurovascular coupling in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), which may provide a new mechanistic perspective into understanding numerous brain diseases.

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