Abstract #3487

Evaluation of whole-brain oxygen metabolism in Alzheimer's disease using QSM and quantitative BOLD

Aocai Yang^1,2, Hangwei Zhuang^3,4, Guolin Ma², and Yi Wang^3,5

¹Peking Union Medical College, Beijing, China, ²Department of Radiology, China–Japan Friendship Hospital, Beijing, China, ³Department of Biomedical Engineering, Cornell University, New York, NY, United States, ⁴Weill Cornell Medical College, Department of Radiology, New York, NY, United States, ⁵Department of Radiology, Weill Cornell Medical College, New York, NY, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease We assessed the whole-brain oxygen metabolism perturbations in AD using QSM and quantitative BOLD. mGRE data and QQ model was employed to calculate OEF and ASL data was used to reconstruct CBF map. The CMRO2 can be estimated from CBF and OEF based on Fick’s principle. Our results demonstrated a characteristic whole-brain hypoperfusion and hypometabolism pattern in AD, predominantly located within default-mode network. Additionally, decreased CBF and CMRO2 in substructures of bilateral hippocampus strongly correlated with global cognition. QQ model-based noninvasively quantitative measurements have a great potential to be complementary biomarkers for evaluating cognitive impairment in AD.

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