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Abstract #3487

Evaluation of whole-brain oxygen metabolism in Alzheimer's disease using QSM and quantitative BOLD

Aocai Yang1,2, Hangwei Zhuang3,4, Guolin Ma2, and Yi Wang3,5
1Peking Union Medical College, Beijing, China, 2Department of Radiology, China–Japan Friendship Hospital, Beijing, China, 3Department of Biomedical Engineering, Cornell University, New York, NY, United States, 4Weill Cornell Medical College, Department of Radiology, New York, NY, United States, 5Department of Radiology, Weill Cornell Medical College, New York, NY, United States

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease We assessed the whole-brain oxygen metabolism perturbations in AD using QSM and quantitative BOLD. mGRE data and QQ model was employed to calculate OEF and ASL data was used to reconstruct CBF map. The CMRO2 can be estimated from CBF and OEF based on Fick’s principle. Our results demonstrated a characteristic whole-brain hypoperfusion and hypometabolism pattern in AD, predominantly located within default-mode network. Additionally, decreased CBF and CMRO2 in substructures of bilateral hippocampus strongly correlated with global cognition. QQ model-based noninvasively quantitative measurements have a great potential to be complementary biomarkers for evaluating cognitive impairment in AD.

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