Abstract #3492

Reorganization of Functional Connectivity between White and Grey Matters during Normal Aging

Yurui Gao^1,2, Yu Zhao^2,3, Muwei Li^2,3, Dylan R Lawless^2,4, Kurt G Schilling³, Lyuan Xu^2,4, Andrea T Shafer⁵, Lori L Beason-Held⁵, Susan M Resnick⁵, Baxter P Rogers^2,3, Zhaohua Ding^2,4, Adam W Anderson^1,2, Bennett A Landman^1,2,3,4, and John C Gore^1,2,3

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²VUIIS, Vanderbilt University Medical Center, Nashville, TN, United States, ³Radiology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, United States, ⁵Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, United States

Synopsis

Keywords: Brain Connectivity, AgingResting state BOLD signals in white matter (WM) bundles have been found to be partially synchronized with signals in gray matter (GM) volumes, suggesting WM-GM functional connectivity (FC). However, little is known about whether or how these relationships change during normal aging, and traditional graph models are inappropriate. We introduced a novel graph model and applied it to assess WM-GM network properties in 1,462 healthy subjects (22–96years) and their age effects. Results show heterogenous alterations in WM-GM rsFC over adulthood with decreases mainly during late adulthood. Our results demonstrate there is substantial reorganization of WM-GM correlations during normal aging.

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