Abstract #3494

Acute Effects of Psilocybin and Salvinorin-A on Functional Connectivity

Frederick Andrew Bagdasarian¹, Hanne Hansen^1,2, Chi-Hyeon Yoo¹, Michael Placzek¹, Jacob Hooker¹, and Hsiao-Ying Wey¹

¹Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, ²Neurobiology Research Unit, Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Netherlands

Synopsis

Keywords: Brain Connectivity, fMRI (resting state)

This work utilized fMRI to assess the influence of the psychedelics, Psilocybin, a serotonergic agonist, and Salvinorin-A, a kappa-opioid receptor (KOR) agonist, on functional connectivity (FC) in non-human primates. We used a seed-based FC analysis, probing regions of interest associated with psychedelic hallucinogens. Our findings highlight the overlapping and differing influence of these substances on FC relative to the subcomponents of the default mode network and the claustrum. This work may provide insight on the mechanisms of action of psychedelics that target differing receptor systems.

Key Words: Functional connectivity; Claustrum; DMN; Psychedelics.

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