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Abstract #3495

Effect of acute severe hypoxic environment on brain network connectivity

Daehun Kang1, Koji Uchida2, Clifton Haider3, Erin Gray1, Myung-Ho In1, Joshua Trzasko1, Norbert Campeau1, Kirk Welker1, Jeffrey Gunter1, Yunhong Shu1, Matt A Bernstein1, Max Trenerry4, David III Holmes3, Michael Joyner2, Timothy Curry2, and John III Huston 1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States, 3Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States, 4Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States

Synopsis

Keywords: Brain Connectivity, fMRI, HypoxiaAcute exposure to a severely low oxygen environment (<10%) can cause temporary deterioration of cognitive performance. To better understand the mechanism of the hypoxic-related temporary cognitive impairment in the human brain, we examined functional connectivity changes in brain networks during acute severe hypoxia while subjects performed a cognitive task. The acute severe hypoxic environment temporarily increases functional connectivity among salience (SN), default mode (DMN), executive central (ECN), sensorimotor, and visuospatial networks. We observed that increased connectivity of SN to DMN and to ECN during acute severe hypoxia is related with the behavioral cognitive deterioration.

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Keywords