Abstract #3496

Functional Connectivity in Smokeless Tobacco Dependent Users in a Craving ‘Primed’ State

Vasishta Polisetty¹, S Senthil Kumaran², Priyanka Bhat³, Pankaj .², Anju Dhawan¹, and Sonali Jhanjhee¹

¹Dept of Psychiatry, All India Institute of Medical Sciences, New Delhi, New Delhi, India, ²Dept of NMR, All India Institute of Medical Sciences, New Delhi, New Delhi, India, ³Biomedical Engineering, Indian Institute of Technology, Delhi, New Delhi, India

Synopsis

Keywords: Psychiatric Disorders, Brain Connectivity, AddictionTobacco is a leading cause of preventable cancer and death and is consumed in various forms. There is a paucity of literature regarding cue-induced craving in smokeless tobacco, commonly found in the South East Asian Region. This study aimed to investigate the functional connectivity in a ‘primed’ state after cue-induced craving. We found facilitatory connectivity within salience network (SN) and inhibitory connectivity between default mode network (DMN) and anterior cingulate cortex (ACC) in smokeless tobacco users.

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