Abstract #3503

Preliminary evaluation of brain neural networks following chemogenetically-induced activation of the motor cortex in rats

Mathias Lysholt Mathiasen¹, Sascha Gude¹, Henrik Lundell¹, Hartwig Roman Siebner^1,2,3, and Nathalie Just¹

¹DRCMR, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark, ²Department of Neurology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark, ³Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Synopsis

Keywords: Brain Connectivity, fMRI (resting state), ChemogeneticsGenetic and viral tools coupled with functional magnetic resonance imaging (fMRI) techniques provide unique opportunities to investigate the functional neural networks in the rodent brain. Chemogenetic tools can be used to selectively activate or inhibit specific neural populations and their projections, and in combination with fMRI, can reveal the underlying mechanisms of brain activity. We present early resting-state and pharmacological fMRI results regarding CNO-mediated activation of the hM3Dq DREADD in the motor cortex of rats.

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