Abstract #3504

Functional relevance of cholinergic projections in the ChAT-IRES-Cre mouse brain using optogenetic functional MRI

Thajunnisa Ashraf Sajitha¹, Russell W Chan¹, Patryk Filipiak², Muneeb Faiq¹, Royce P Lee¹, Steven H Baete², and Kevin C Chan^1,3,4

¹Department of Ophthalmology, NYU Langone Health, New York University Grossman School of Medicine, New York, NY, USA 10017, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU Langone Health, New York University Grossman School of Medicine, New York, NY, USA 10017, New York, NY, United States, ³Department of Radiology, New York University Grossman School of Medicine, New York, NY, USA 10017, New York, NY, United States, ⁴Center for Neural Science, NYU College of Arts and Sciences, New York, NY, 10003, New York, NY, United States

Synopsis

Keywords: Brain Connectivity, fMRI (task based)Recent studies have mapped the whole-brain cholinergic projections in the mouse brain. However, their functional relevance remains unclear. In this study, we used optogenetic functional MRI to observe the functional brain responses upon stimulating the cholinergic neurons in the basal forebrain. We observed significant BOLD percentage change in 14 out of 19 brain regions evaluated, indicating their functional relevance to the cholinergic system.

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